IMMUNOLOGIC ALTERATION IN BLADDER TUMORS II

Induced immunologic response to tumors.

A tumoricidal system has been described utilizing a two-step process which, first, specifically alters the antigenic nature of a tumor cell and, second, adds a heterologous cytotoxic anti body without affecting normal cells. The antigenic structure of the tumor cell is altered by the nitrogen mustard, L-phenylalanine mustard, and a specific antibody is made to this mustard by injecting it into ...

PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.

Bladder tumors constitute a very heterogeneous disease. Superficial tumors are characterized by a high prevalence of FGFR3 mutations and chromosome 9 alterations. High-grade and muscle-invasive tumors are characterized by Tp53 mutations and aneuploidy. We have analyzed the sequence of exons 9 and 20 of PIK3CA in a panel of bladder tumors covering the whole spectrum of the disease. DNA from form...

Immunologic Control of Tumors by In Vivo

Tumor markers of bladder cancer: the schistosomal bladder tumors versus non-schistosomal bladder tumors

BACKGROUND The aim of this study is to comparatively elucidate the underlying molecular pathways and clinicopathological criteria in schistosomal bladder tumor (SBT) versus non-schistosomal bladder tumor (NSBT). METHODS This study explored the role of p53, p16, bcl-2, ki-67, c-myc, Rb and EGFR, by using Immunohistochemistry assay, in 45 SBT and 39 NSBT patients in comparison with 16 schistoso...

MRI of the Bladder in Patients Suspected of Bladder Tumors

Objective: To prospectively evaluate the use of MRI for the detecting of bladder tumors and the Tstage using T2W, T1W and diffusion-weighted images (DWI). Material and methods: Twenty-eight consecutive patients (21 men, 7 women; age range, 20 82 years; mean age, 62.8 years) suspected of bladder tumors underwent MRI, flexible cystoscopy and transurethral resection (TURB). The presence of bladder...